Perpustakaan Universitas Padjajaran
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D89- Hydrogel Film Forming Spray Formulation Containing Propolis Based Nanostructured Lipid Carriers of α-Mangostin For Diabetic Wound Repair (Cecep Suhandi; Prof. Nasrul Wathoni, M.Si., Ph.D; Prof. Muchtaridi, Ph.D., M.Si; Prof. Sabreena Safuan, Ph.D)

Chronic diabetic wounds present a major clinical challenge due to persistent inflammation, delayed healing, and high susceptibility to infection. ...

  • CodeCallNoLokasiKetersediaan
    FFUP20260024D89Tersedia
  • Perpustakaan
    Fakultas Farmasi
    Judul Seri
    -
    No. Panggil
    D89
    Penerbit Fakultas Farmasi Universitas Padjadjaran : Jatinangor.,
    Deskripsi Fisik
    -
    Bahasa
    English
    ISBN/ISSN
    -
    Klasifikasi
    D89
    Tipe Isi
    -
    Tipe Media
    -
    Tipe Pembawa
    -
    Edisi
    -
    Subyek
    -
    Info Detil Spesifik
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    Pernyataan Tanggungjawab
  • Chronic diabetic wounds present a major clinical challenge due to persistent inflammation, delayed healing, and high susceptibility to infection. α-Mangostin (αM), a xanthone compound with demonstrated antioxidant, anti-inflammatory, and antimicrobial properties, holds significant potential for promoting wound repair. However, its poor water solubility limits its therapeutic application. Encapsulation of αM in propolis-based nanostructured lipid carriers (NLC-P-αM) improves its solubility and stability. This study aims to develop, characterize, and evaluate a hydrogel film-forming spray (HFFS) incorporating NLC-P-αM (HFFS-NLC-P-αM) as an innovative approach for diabetic wound treatment. The formulation was prepared using chitosan, Carbopol 940, and sodium carboxymethyl cellulose, and was assessed for pH, viscosity, spray angle, spray weight uniformity, particle size, zeta potential, and entrapment efficiency. The optimized formulation, containing 0.1% Carbopol 940, exhibited favorable physicochemical properties: pH 7.30 ± 0.01, viscosity 19.97 ± 2.12 mPa·s, spray angle 62.02 ± 3.83°, particle size 85.17 ± 2.55 nm, zeta potential −13.90 ± 2.18 mV, and entrapment efficiency of 91.31 ± 0.58%. The formulation was stable over 28 days and followed Higuchi release kinetics (R² = 0.998). Morphological analysis via TEM confirmed spherical nanoparticles. Cytocompatibility testing on NIH-3T3 cells showed good viability (105.74 ± 16.71%). In vivo studies in alloxan-induced diabetic mice revealed significantly enhanced wound healing, with wound closure reaching 99.53 ± 1.04% compared to 89.24 ± 3.04% with silver sulfadiazine (p < 0.01). Histological analysis demonstrated improved follicle regeneration and epidermal remodeling. In conclusion, HFFS-NLC-P-αM exhibits excellent stability, biocompatibility, sustained release behavior, and superior wound healing efficacy in diabetic models. This novel delivery system synergistically integrates nanotechnology and natural therapeutics, offering a promising strategy for the management of chronic diabetic wounds.
    Keywords: α-mangostin, propolis, nanostructured lipid carrier, hydrogel film-forming spray, diabetic wound healing

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