Perpustakaan Universitas Padjajaran
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T346- Effect of Polyvinylpyrrolidone K30 and Eudragit L100 on the Recrystallization Inhibition of Ternary Alpha Mangostin Solid Dispersion (Salma Amaliah; Arif Budiman, M.Si., Ph.D; Dr. Diah Lia Aulifa, M.Si)

Alpha-mangostin (AM), a xanthone compound extracted from the pericarp of Garcinia mangostana, exhibits poor aqueous solubility and low oral ...

  • CodeCallNoLokasiKetersediaan
    FFUP20260009T346Tersedia
  • Perpustakaan
    Fakultas Farmasi
    Judul Seri
    -
    No. Panggil
    T346
    Penerbit Fakultas Farmasi Universitas Padjadjaran : Jatinangor.,
    Deskripsi Fisik
    -
    Bahasa
    English
    ISBN/ISSN
    -
    Klasifikasi
    T346
    Tipe Isi
    -
    Tipe Media
    -
    Tipe Pembawa
    -
    Edisi
    -
    Subyek
    -
    Info Detil Spesifik
    -
    Pernyataan Tanggungjawab
  • Alpha-mangostin (AM), a xanthone compound extracted from the pericarp of Garcinia mangostana, exhibits poor aqueous solubility and low oral bioavailability. Among several approaches, amorphous solid dispersions (ASDs) have demonstrated efficacy for poorly water-soluble drugs, but they are limited by low wettability and poor physicochemical stability. Adding a third component to generate ternary solid dispersions (TSD) can overcome these limitations. This study aimed to prepare and comprehensively evaluate TSDs of AM using polyvinylpyrrolidone (PVP) K30 and Eudragit (EUD) L100. The study is divided into four main phases: crystalline inhibition of AM in TSD, preparation of TSD from AM, characterization of the formula, and evaluation of pharmaceutical properties of TSD of AM. The presence of polymer can maintain supersaturation for varying durations: EUD L100 for 30 minutes to 2 hours, PVP K30 for 12 hours, whereas TSDs maintained supersaturation for over 72 hours, indicating a synergistic effect in enhancing wettability and inhibiting recrystallization. Amorphization in TSD-AM was confirmed by homogenous morphology in scanning electron microsopy (SEM), halo pattern in powder X-ray diffraction (PXRD), and a single glass transition in the differential scanning calorimetry (DSC). Fourier transform infrared (FTIR) spectroscopy revealed hydrogen-bonding interactions between the carbonyl group of AM and the hydroxyl groups of the polymers. In the dissolution test, TSD-AM rapidly achieved amorphous solubility within 3-45 min and maintained long-term supersaturation, compared to crystalline AM and binary AM. TSD-AM also retained PXRD halo patterns after 30 day of storage, even under high humidity conditions. These results highlight the synergistic role of PVP K30 and EUD L100 in sustaining supersaturation, preventing recrystallization, and improving the solubility, dissolution, and stability of AM.
    Keywords: alpha-mangostin, eudragit, inhibition of recrystallization, PVP, ternary solid dispersion.

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