Perpustakaan Universitas Padjajaran
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D71- Anti Oral Mucosal Ulceration Activity and Mechanism of The Ethanol Extract of Kaemferia galanga L. Rhizome Via Inhibition of COX-2 Expression (Indah Suasani Wahyuni; Prof. Dr. Jutti Levita, M.Si; Dr. Irna Sufiawati, drg., Sp.PM. Subsp. Inf. (K); Prof. Dr. Wipawee Nitayananta)

Oral health is an integral part of overall body health. Therefore, oral mucosal inflammation can
impact the body's health. Oral mucosal ...

  • CodeCallNoLokasiKetersediaan
    FFUP20250048D71Tersedia
  • Perpustakaan
    Fakultas Farmasi
    Judul Seri
    -
    No. Panggil
    D71
    Penerbit Fakultas Farmasi Universitas Padjadjaran : Jatinangor.,
    Deskripsi Fisik
    -
    Bahasa
    English
    ISBN/ISSN
    -
    Klasifikasi
    D71
    Tipe Isi
    -
    Tipe Media
    -
    Tipe Pembawa
    -
    Edisi
    -
    Subyek
    -
    Info Detil Spesifik
    -
    Pernyataan Tanggungjawab
  • Oral health is an integral part of overall body health. Therefore, oral mucosal inflammation can
    impact the body's health. Oral mucosal inflammation can be managed by administering anti-
    inflammatory drugs, both steroids and non-steroidal, but sometimes cause side effects, especially if
    used in the long term and large doses. Research on medicinal plants for alternatives has recently
    been carried out. One of the plants in Indonesia that is known to have an anti-inflammatory effect is
    Kaempferia galanga L. The rhizome part of this plant contains a lot of secondary metabolites. This
    has not been widely explored in plants harvested in the rainy and dry seasons, according to
    Indonesia's geographical conditions. The difference in harvest time between these two seasons will
    affect the content of secondary metabolites. One of the anti-inflammatory mechanisms that can be
    investigated for drug development is through the cyclooxygenase (COX) enzyme inhibition
    pathway, particularly COX-2. Thus, this study aimed to explore the potential of the medicinal plant
    Kaempferia galanga L. as an anti-oral mucosal ulcer, which is often used in traditional medicine,
    has anti-inflammatory effects, and is known to have low toxicity. The research methods used were
    phytochemical screening/color test method, spectrophotometric analysis, and chromatogram
    profiles analysis: Thin Layer Chromatography (TLC) and Reversed-Phase High-Performance
    Liquid Chromatography (RP-HPLC), for the identification of secondary metabolites in the ethanolic
    extract of K. galanga L. (EEKG). Ethyl p-methoxycinnamate (EPMC) levels in the EEKG from
    plants harvested in the rainy season (EEKG-R) and those harvested in the dry season (EEKG-D)
    were determined using the validated RP-HPLC method. The in vitro studies were carried out to
    obtain the IC50 value of the EEKG in inhibiting prostaglandin production catalyzed by COX-2, as
    well as in vivo studies on acetic acid 70%-induced oral mucosal ulcers in Wistar rats. The effect of
    EEKG topical application was measured macroscopically, histopathologically, and using the
    western blot method. The results showed that the secondary metabolites contained in the EEKG
    were Polyphenols, Flavonoids, Alkaloids, Tannins, Terpenoids, and Saponins; EPMC and
    flavonoids detected in the EEKG using TLC, meanwhile, only EPMC was detected in the EEKG
    using RP-HPLC. The EPMC level of the EEKG-R was 10 times greater (0.01%) than that of EEKG-
    D (0.001%). The relative IC50 of EEKG was 39.85 ppm (r = 1) and the growth IC50 of EEKG was
    58.88 ppm (r2 = 0.97/r = 0.99). This in vitro study also revealed that low-dose EEKG (15.625 ppm
    and 31.25 ppm) showed a statistically significant (p

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